Scientific activities of the Institute were of interdisciplinary character since the very beginning. Practically since its foundation the Institute has pursued four main research directions: a) The History of Byzantium and Byzantine-Southern Slavic Relations, b) Byzantine Sources for the History of the Peoples of Yugoslavia c) Byzantine Literature and the Medieval Greek Language, d) Byzantine and Post-Byzantine Art. Two projects have also been launched within the same framework, in cooperation with similar institutions abroad, the initial results of which have already been published: The Greek Documents of the Hilandar Monastery (with The Institute for Byzantine Studies in Paris), Byzantine Inscriptions on Portraits from Macedonia (with The Institute for Byzantine Studies in Athens). From 2002 to 2005, so-called target projects were introduced and developed (including the already mentioned cooperation with foreign partners): Actes de Chilandar II; Donors’ Inscriptions on Frescoes from the XIIth to the XIIIth Century; The Internal Transformation of Byzantium from the Xth to the XIIth Century; Byzantine Sources for the History of the Peoples of Yugoslavia, vol. V. In the year 2006 a five-year cycle of combined projects was initiated: The Last Century of Byzantium and Serbia (project leader R. Radić), The Byzantine World Changes (Xth-XIIth Centuries) (project leader Lj. Maksimović), Wall Painting and Inscriptions of the XIVth and XVth Centuries (project leader G. Subotić). Scientific activities of the Institute are currently joined in the four-year project of an interdisciplinary character, Tradition, innovation and identity in the Byzantine world (project leader Lj. Maksimović), which has brought together researchers from Belgrade and abroad.
The Instititute was the chief organizer of several scholarly national and international events. In the year 1961, the 12th International Congress of Byzantine Studies was organized in Ohrid. On the 22nd International Congress of Byzantine Studies in Sofia (august 2011), the decision was made to entrust the organization of the next, 23rd International Congress of Byzantine Studies, to Belgrade (2016). Belgrade was also host of the 2nd International Congress of Byzantine Studies in 1927.
National conferences of Byzantine Studies have been taking place every five years, for the past two decades. The first was organized in Zadar in 1990 (Yugoslav conference of Byzantine Studies), the second was held in Studenica (1995), the third in Kruševac (2000) and the last two conferences were held in Belgrade (2005, 2010). These national conferences always bring together researchers of all generations dealing with Byzantine studies as well as other closely related scientific disciplines.
The Institute has participated, since the very beginning, in the organization of various scientific events, which were the result of bilateral cooperation. During the past few years, such events were related to the Bulgarian – Serbian (2008) and French – Serbian (2010) cooperation. It is also planned to hold several other scientific meetings, especially a joint conference with colleagues from Greece.